Agenda
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Learning outcomes
At the end of the Toxicokinetics??webinar you will be able to:
- Explain the difference between toxicokinetics and toxicodynamics
- Outline the ways knowledge of toxicokinetics can be used in your daily work
- Explain what is meant by the acronym ???ADME???
- Describe what happens during absorption and the ways in which physicochemical properties can be used in predicting the extent of absorption
- Explain what is meant by ???ionisation??? and ???polar/non-polar??? molecules
- Explain what is meant by ???first pass metabolism??? and how this influences toxicity
- Explain the significance of absorption by the intravenous route and intraperitoneal route
- Define the term ???bioavailability??? and its significance to toxicity
- Explain what is meant by distribution and how this can impact toxicity.
- Define the term ???apparent volume of distribution??? and its significance
- Outline the role of metabolism (phase 1 and phase 2) and its relationship to toxicity (with specific reference to benzene and paracetamol as examples)
- Explain the significance of hepatic injury/disease to the metabolic process
- Explain the significance of intraspecies variations and what is meant by this
- Define the term ???excretion/elimination??? and the way in which elimination kinetics is used (zero order and first order) with specific examples
- Explain what is meant by the biological half-life of a chemical and its significance
- Explain how the area under the curve can be used (AUC) to assess bioavailability
- Outline current methods which are available for the assessment of toxicokinetics and current regulatory requirements.
